Bilim d\u00fcnyas\u0131 son zamanlarda d\u00fcnyay\u0131 sars\u0131yor! \u0130lk olarak, Hindistan'daki Ulusal \u0130mm\u00fcnoloji Enstit\u00fcs\u00fc'nden Vijay K. Yadav'\u0131n ekibi \u300aScience\u300b dergisinde Taurin'in ya\u015flanmay\u0131 yava\u015flatma konusunda inan\u0131lmaz bir potansiyele sahip oldu\u011funu ortaya koydu. Ard\u0131ndan, Xijing Hastanesi'nden akademisyen Fan Daiming'in ekibi, en iyi dergi \u300aCell\u300b'de bir kez daha s\u0131cak bir tart\u0131\u015fmay\u0131 tetikleyen bir makale yay\u0131nlad\u0131: Taurin asl\u0131nda t\u00fcm\u00f6r ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131na yard\u0131mc\u0131 olabilir!<\/p>\n
Taurin ya\u015flanmay\u0131 yava\u015flatmay\u0131 nas\u0131l ba\u015far\u0131yor?<\/p>\n
Vijay K. Yadav'\u0131n ekibi, Taurinin h\u00fccresel ya\u015flanmay\u0131 azaltt\u0131\u011f\u0131n\u0131, telomeraz\u0131 korudu\u011funu, mitokondriyal disfonksiyonu engelledi\u011fini, DNA hasar\u0131n\u0131 azaltt\u0131\u011f\u0131n\u0131 ve enflamatuar tepkileri hafifletti\u011fini ve ya\u015flanma s\u00fcrecini yava\u015flatmak i\u00e7in yeni bir olas\u0131 strateji sa\u011flad\u0131\u011f\u0131n\u0131 buldu, peki tam olarak nas\u0131l \u00e7al\u0131\u015f\u0131yor?<\/p>\n
Deneyler, Taurin konsantrasyonlar\u0131n\u0131n ya\u015flanmayla birlikte azald\u0131\u011f\u0131n\u0131, ancak taurin takviyesinin di\u015fi farelerin ortalama \u00f6mr\u00fcn\u00fc 12%, erkek farelerin \u00f6mr\u00fcn\u00fc ise 10% art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Taurin eksikli\u011finin ya\u015flanman\u0131n bir nedeni olup olmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in ara\u015ft\u0131rmac\u0131lar, Taurinin ya\u015flanmayla m\u00fccadele etti\u011fi \u00e7oklu mekanizmalar\u0131 do\u011frulad\u0131.<\/p>\n
1\u3001 H\u00fccresel ya\u015flanmay\u0131 azalt\u0131r: Taurin takviyesinin fare dokular\u0131nda SA \u03b2-Gal boyanmas\u0131n\u0131n (h\u00fccresel ya\u015flanman\u0131n bir biyobelirteci) yo\u011funlu\u011funu azaltabildi\u011fi deneysel olarak g\u00f6zlemlenmi\u015ftir. N\u00f6ronal k\u00fclt\u00fcr deneylerinde, taurin takviyesi p-metoksi oksalil\u00fcre (h\u00fccresel ya\u015flanmay\u0131 ind\u00fckleyen bir DNA hasar\u0131 ajan\u0131) ile muamele edilen n\u00f6ronlar\u0131n hayatta kalma oran\u0131n\u0131 art\u0131rm\u0131\u015ft\u0131r.<\/p>\n
2\u3001Telomeraz fonksiyonunun korunmas\u0131: Telomeraz eksikli\u011fi olan bir zebra bal\u0131\u011f\u0131 modelinde (tert-\/-(G2)), taurin takviyesi 2 g\u00fcnl\u00fck embriyonik ya\u015ftan (dpf) ba\u015flayarak h\u00fccresel ya\u015flanmay\u0131 engellemi\u015f ve 300 mM ve 10 mM konsantrasyonlar\u0131nda zebra bal\u0131\u011f\u0131 embriyolar\u0131n\u0131n hayatta kalma oran\u0131n\u0131 art\u0131rm\u0131\u015ft\u0131r.<\/p>\n
3\u3001Mitokondriyal disfonksiyonun inhibisyonu: tRNALeu(UUA)'daki tm5U-tRNA seviyesini \u00f6l\u00e7erek, taurin takviyeli farelerin ya\u015flanma s\u0131ras\u0131nda daha y\u00fcksek tm5U-tRNA modifikasyon seviyelerini korudu\u011fu ve bunun da ND6 proteininin (mitokondriyal kompleks I'in \u00f6nemli bir bile\u015feni) translasyonunu te\u015fvik etmeye yard\u0131mc\u0131 oldu\u011fu bulunmu\u015ftur.<\/p>\n
4 \u3001 Azalt\u0131lm\u0131\u015f DNA hasar\u0131: Taurin takviyesi, ya\u015fl\u0131 farelerde serum 8-OH-dG (oksidatif DNA hasar\u0131n\u0131n bir g\u00f6stergesi) seviyelerini d\u00fc\u015f\u00fcrm\u00fc\u015ft\u00fcr. Buna ek olarak, deneyler taurin takviyeli farelerin kaslar\u0131nda DNA hasar\u0131 belirteci H2Ax seviyelerinin daha d\u00fc\u015f\u00fck oldu\u011funu tespit etmi\u015ftir, bu da Taurin'in DNA hasar\u0131n\u0131 azaltarak h\u00fccreleri koruyabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n
<\/p>\n
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The scientific community has been rocking the world recently! First, Vijay K. Yadav’s team at the …<\/p>","protected":false},"author":4,"featured_media":530,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-529","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogs"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/posts\/529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/comments?post=529"}],"version-history":[{"count":0,"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/posts\/529\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/media\/530"}],"wp:attachment":[{"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/media?parent=529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/categories?post=529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.honrychemical.com\/tr\/wp-json\/wp\/v2\/tags?post=529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}