N,N-Dimethylformamide (DMF), with the molecular formula C₃H₇NO, is a colorless to slightly yellow liquid amide compound. It is a polar aprotic solvent characterized by a high dielectric constant and dipole moment, making it an excellent solvent for a wide range of organic and inorganic compounds.
- CAS Number: 68-12-2
- Molecular Weight: 73.09 g/mol
- Molecular Structure: CH₃-NH-C=O
- Purity: ≥99.9%
Physical & Chemical Properties
- Appearance: Colorless to slightly yellow liquid
- Boiling Point: 153°C
- Melting Point: -61°C
- Density: 0.945 g/cm³ at 20°C
- Flash Point: 58°C
- Refractive Index: 1.4305 at 20°C
- Vapor Pressure: 3.7 mmHg at 25°C
- Dielectric Constant: 36.7
- Dipole Moment: 3.86 D
- Solubility: Miscible with water and most organic solvents
Applications
N,N-Dimethylformamide is a highly versatile chemical raw material and an excellent solvent, widely used in various industrial and laboratory applications:
- Polymer Industry:Used in the production of acrylic fibers and plastics.
- Pharmaceuticals:Employed as a solvent in peptide coupling reactions.
- Pesticides:Acts as a solvent in the development and production of pesticides.
- Adhesives and Coatings:Incorporated into formulations for adhesives and coatings.
- Chemical Synthesis:Used as a solvent and reagent in various organic reactions, including the Vilsmeier-Haack reaction for formylation of aromatic compounds.
Storage & Handling
- Storage Conditions: Store in a cool, well-ventilated warehouse. The storage temperature should not exceed 37°C.
- Safety Precautions: Keep away from fire and heat sources. Keep the container tightly sealed.
- Incompatibilities: Store separately from oxidizing agents, reducing agents, halogens, and other incompatible materials.
Safety Information
- Hazard Classification: Flammable liquid and vapor. Causes serious eye irritation. Harmful if swallowed or inhaled. May damage fertility or the unborn child.
- Precautionary Measures: Wear protective gloves/protective clothing/eye protection/face protection. Keep away from heat/sparks/open flames/hot surfaces. No smoking.
- First Aid Measures: In case of contact, immediately call a poison center or doctor/physician. If on skin, wash with plenty of soap and water. If inhaled, remove person to fresh air and keep comfortable for breathing.
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