N,N-Dimethylformamide (DMF), with the molecular formula C₃H₇NO, is a colorless to slightly yellow liquid amide compound. It is a polar aprotic solvent characterized by a high dielectric constant and dipole moment, making it an excellent solvent for a wide range of organic and inorganic compounds.

  • CAS Number: 68-12-2
  • Molecular Weight: 73.09 g/mol
  • Molecular Structure: CH₃-NH-C=O
  • Purity: ≥99.9%

Physical & Chemical Properties

  • Appearance: Colorless to slightly yellow liquid
  • Boiling Point: 153°C
  • Melting Point: -61°C
  • Density: 0.945 g/cm³ at 20°C
  • Flash Point: 58°C
  • Refractive Index: 1.4305 at 20°C
  • Vapor Pressure: 3.7 mmHg at 25°C
  • Dielectric Constant: 36.7
  • Dipole Moment: 3.86 D
  • Solubility: Miscible with water and most organic solvents

Applications

N,N-Dimethylformamide is a highly versatile chemical raw material and an excellent solvent, widely used in various industrial and laboratory applications:

  • Polymer Industry: Used in the production of acrylic fibers and plastics.
  • Pharmaceuticals: Employed as a solvent in peptide coupling reactions.
  • Pesticides: Acts as a solvent in the development and production of pesticides.
  • Adhesives and Coatings: Incorporated into formulations for adhesives and coatings.
  • Chemical Synthesis: Used as a solvent and reagent in various organic reactions, including the Vilsmeier-Haack reaction for formylation of aromatic compounds.

Storage & Handling

  • Storage Conditions: Store in a cool, well-ventilated warehouse. The storage temperature should not exceed 37°C.

  • Safety Precautions: Keep away from fire and heat sources. Keep the container tightly sealed.

  • Incompatibilities: Store separately from oxidizing agents, reducing agents, halogens, and other incompatible materials.

Safety Information

  • Hazard Classification: Flammable liquid and vapor. Causes serious eye irritation. Harmful if swallowed or inhaled. May damage fertility or the unborn child.
  • Precautionary Measures: Wear protective gloves/protective clothing/eye protection/face protection. Keep away from heat/sparks/open flames/hot surfaces. No smoking.
  • First Aid Measures: In case of contact, immediately call a poison center or doctor/physician. If on skin, wash with plenty of soap and water. If inhaled, remove person to fresh air and keep comfortable for breathing.

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